منابع مشابه
Surface modification of PLGA microspheres.
Microspheres made of poly(lactic-co-glycolic acid) (PLGA) are biocompatible and biodegradable, rendering them a promising tool in the context of drug delivery. However, nonspecific adsorption of plasma proteins on PLGA micro- and nanospheres is a main limitation of drug targeting. Poly(L-lysine)-g-poly(ethylene glycol) (PLL-g-PEG), physisorbed on flat metal oxide surfaces, has previously been s...
متن کاملCOMMUNICATIONS Surface Modification of Polyanhydride Microspheres
Polyanhydrides are emerging as a new class of biodegradable polymers for drug delivery.1-3 The degradation of polyanhydride delivery systems is largely through surface erosion, potentially leading to zero-order release of encapsulated drugs.4,5 Recently, the Food and Drug Administration has approved the use of the polyanhydride poly[sebacic acid-co-1,3-bis(p-carboxyphenoxy)propane] to deliver d...
متن کاملDevelopment of Risperidone PLGA Microspheres
The aim of this study was to design and evaluate biodegradable PLGA microspheres for sustained delivery of Risperidone, with an eventual goal of avoiding combination therapy for the treatment of schizophrenia. Two PLGA copolymers (50 : 50 and 75 : 25) were used to prepare four microsphere formulations of Risperidone. The microspheres were characterized by several in vitro techniques. In vivo st...
متن کاملIVIVC of parenteral PLGA microspheres
There have been only a dozen parenteral extended release formulations that are designed to deliver drugs from a week up to 6 months since the first introduction of Lupron Depot® made of poly(lactic-coglycolic acid) (PLGA) microspheres in 1989. All parenteral extended release formulations are made of PLGA in the form of microspheres, solid implants, and in situ forming implants. Over the past fe...
متن کاملPLGA Microspheres Incorporated Gelatin Scaffold: Microspheres Modulate Scaffold Properties
Freeze drying is one of the popular methods of fabrication for poly(lactide-co-glycolide) (PLGA) microspheres incorporated polymer scaffolds. However, the consequence of microspheres incorporation on physical and biological properties of scaffold has not been studied yet. In this study, attempt has been made to characterize the effect of PLGA microsphere incorporation on the physical properties...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2003
ISSN: 1549-3296
DOI: 10.1002/jbm.a.10502